A PLATFORM TRIAL APPROACH TO PROOF-OF-CONCEPT (POC) STUDIES IN AUTISM SPECTRUM DISORDER: AUTISM SPECTRUM POC INITIATIVE (ASPI)

A platform trial approach to proof-of-concept (POC) studies in autism spectrum disorder: Autism spectrum POC initiative (ASPI)

Background: Over the past decade, autism spectrum disorder (ASD) research has blossomed, and multiple clinical trials have tested potential interventions, with varying results and no clear demonstration of efficacy.Lack of clarity concerning appropriate biological mechanisms to target and lack of sensitive, objective tools to identify subgroups and

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Fatigue analysis of aluminum drill pipes

An experimental program was performed to investigate the fundamental fatigue mechanisms of aluminum drill pipes.Initially, the fatigue properties were determined through small-scale tests performed in an optic-mechanical fatigue apparatus.Additionally, full-scale fatigue 2000 dodge durango catalytic converter tests were carried out with three alumi

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Challenges and solutions to the scale-up of porous materials

Abstract With increasing pace, crystalline open frameworks are moving to larger scale, mature applications that stretch as broadly as catalysis, separation, water purification, adsorption, sensing, biomineralization and energy storage.A particular challenge in this development can be the unexpected variation in material properties from batch to bat

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